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KMID : 0360419660020010021
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Korean Journal of Pharmacology
1966 Volume.2 No. 1 p.21 ~ p.29
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Influence of Dichloroisoproterenol and Panax Ginseng on the action of some drugs
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千然淑/Chun, Yun Sook
崔百熙/金致億/林圭復/崔慶壎/Choi, Baik Hi/Kim, Chi Euk/Lim, Kyu Bok/Choi, Kyung Hun
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Abstract
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Dichloroisoproterenol(DCI) is one of the well known β-adrenergic receptor blocking agents. According to Moran and Perkins, DCI has sympathomimetic like action in relatively low concentrations. Fleming and Hawkins confrmed that DCI acts upon the receptors concerned with positive chronotropic and inotropic actions in the heart.
Vogins reported that DCI, in concentration of 5×10^(-8) to 5×10^(-6)g/ml, had properties of sympathomimetic amine causing positive inotropic and chronotropic actions in normal rat atria. And James and Nadeau found that DCI had not only adrenergic blocking effect in moderate and higher concentrations, but it also blocked the effect on the sinus node by vagal stimulation and of directly administered acetylcholine in higher concentrations.
As stated above by many authors, DCI has complicated actions according to its concentrations. Our aim at the present experiments was to study the effects of DCI to the action of ouabain and acetylcholine upon the excised rabbit atria, as well as to the action of barium chloride and acetylcholine upon the excised rabbit intestine.
In addition, Panax Ginseng is widely used as tonics in oriental nations, its pharmacological action, however, has not been clearly established. So we atempted to investigate the effects of the water extract of Panax Ginseng to the action of ouabain and DCI upon both atria and intestine.
The results obtained were as follows.
1) DCI has a negative inotropic effect on the excised rabbit atria at concentration of 10-^(-5) and a positive inotropic effect at concentration of 10^(-6).
2) DCI (at concentration of 10^(-6)) potentiates the positive inotropic effect of ouabain upon the excised rabbit atria.
3) DCI antagonizes the action of acetylcholine upon the excised rabbit atria.
4) The water extract of Panax Ginseng, at concentration of 10^(-3), decreases the contractile force of rabbit atria, and tends to slightly increase that of rabbit atria at 10^(-4).
5) The water extract of Panax Ginseng exhibits a synergistic action with ouabain on the contractile force of rabbit atria.
6) DCI, in concentrations of 10^(-7)~10^(-6), depresses the tone and amplitude of contraction of the excised rabbit intestine. The depression of the intestinal tone markedly appears in pretreatment with reserpine 2mg/kg 24 hours.
7) DCI antagonizes the contractile effect of barium chloride on the excised rabbit atria.
8) DCI has no signifcant influence on the action of acetylcholine upon the excised rabbit intestine.
9) The series of those evidences indicates that DCI has a sympathomimetic-like action and more over a relaxing action directly on the excised rabbit intestine.
10) The water extract of Panax Ginseng in concentrations of 10^(-4)~10^(-3), has transient depression of the intestinal tone, but later gradually recovers its normal motility.
11) The water extract of Panax Ginseng has a synergistic action with ouabain on the intestinal contractility.
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